Ontology highlight
ABSTRACT:
SUBMITTER: Mews P
PROVIDER: S-EPMC9916993 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Mews Philipp P Cunningham Ashley M AM Scarpa Joseph J Ramakrishnan Aarthi A Hicks Emily M EM Bolnick Sarah S Garamszegi Susanna S Shen Li L Mash Deborah C DC Nestler Eric J EJ
Science advances 20230210 6
Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates represent a substantial public health crisis that exacts tremendous personal and financial costs on patients and society. Sharp increases in cocaine use drive the urgent need for better mechanistic insight into this chronic relapsing brain disorder that currently lacks effective treatment options. To investigate the transcriptomic changes involved, we conducted RNA sequencing on two striatal brain regions that ...[more]