Dataset Information

The Causal Association of Irritable Bowel Syndrome with Multiple Disease Outcomes: A Phenome-Wide Mendelian Randomization Study.

ABSTRACT:

Background

This study aimed to identify novel associations between irritable bowel syndrome (IBS) and a broad range of outcomes.

Methods

In total, 346,352 white participants in the U.K. Biobank were randomly divided into two halves, in which a genome-wide association study (GWAS) of IBS and a polygenic risk score (PRS) analysis of IBS using GWAS summary statistics were conducted, respectively. A phenome-wide association study (PheWAS) based on the PRS of IBS was performed to identify disease outcomes associated with IBS. Then, the causalities of these associations were tested by both one-sample (individual-level data in U.K. Biobank) and two-sample (publicly available summary statistics) Mendelian randomization (MR). Sex-stratified PheWAS-MR analyses were performed in male and female, separately.

Results

Our PheWAS identified five diseases associated with genetically predicted IBS. Conventional MR confirmed these causal associations between IBS and depression (OR: 1.07, 95%CI: 1.01-1.14, p = 0.02), diverticular diseases of the intestine (OR: 1.13, 95%CI: 1.08-1.19, p = 3.00 × 10^-6), gastro-esophageal reflux disease (OR: 1.09, 95%CI: 1.05-1.13, p = 3.72 × 10^-5), dyspepsia (OR: 1.21, 95%CI: 1.13-1.30, p = 9.28 × 10^-8), and diaphragmatic hernia (OR: 1.10, 95%CI: 1.05-1.15, p = 2.75 × 10^-5). The causality of these associations was observed in female only, but not men.

Conclusions

Increased risks of IBS is found to cause a series of disease outcomes. Our findings support further investigation on the clinical relevance of increased IBS risks with mental and digestive disorders.

SUBMITTER: Li C

PROVIDER: S-EPMC9918111 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

The Causal Association of Irritable Bowel Syndrome with Multiple Disease Outcomes: A Phenome-Wide Mendelian Randomization Study.

Li Chunyang C Chen Yilong Y Chen Yi Y Ying Zhiye Z Hu Yao Y Kuang Yalan Y Yang Huazhen H Song Huan H Zeng Xiaoxi X

Journal of clinical medicine 20230131 3

<h4>Background</h4>This study aimed to identify novel associations between irritable bowel syndrome (IBS) and a broad range of outcomes.<h4>Methods</h4>In total, 346,352 white participants in the U.K. Biobank were randomly divided into two halves, in which a genome-wide association study (GWAS) of IBS and a polygenic risk score (PRS) analysis of IBS using GWAS summary statistics were conducted, respectively. A phenome-wide association study (PheWAS) based on the PRS of IBS was performed to ident ...[more]

PMID: 36769754

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Dataset Information

The Causal Association of Irritable Bowel Syndrome with Multiple Disease Outcomes: A Phenome-Wide Mendelian Randomization Study.

Background

Methods

Results

Conclusions

Publications

The Causal Association of Irritable Bowel Syndrome with Multiple Disease Outcomes: A Phenome-Wide Mendelian Randomization Study.

Similar Datasets

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