Catechol-O-methyltransferase Inhibitors from Calendula officinalis Leaf.

ABSTRACT: Calendula officinalis is commonly known as marigold and its flowers are used in herbal medicines, cosmetics, perfumes, dyes, pharmaceutical preparations, and food products. However, the utility of its leaves has not been studied in depth. The purpose of the present study was to identify the major compounds in C. officinalis leaves and to determine the inhibitory properties of the isolated compounds toward human catechol-O-methyltransferase (COMT), a key neurotransmitter involved in Parkinson's disease and depression. We isolated and identified ten compounds, including two phenylpropanoids and seven flavonoids, from C. officinalis leaf extracts, of which four flavonoids were identified from C. officinalis leaves for the first time. Eight compounds exhibite

SUBMITTER: Kadowaki W 

PROVIDER: S-EPMC9919311 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature