Ontology highlight
ABSTRACT:
SUBMITTER: Akbar H
PROVIDER: S-EPMC9926331 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Akbar Hameed H Cao Jun J Wang Dongmei D Yuan Xiao X Zhang Manjuan M Muthusamy Saravanakumar S Song Xiaoyu X Liu Xu X Aikhionbare Felix F Yao Xuebiao X Gao Xinjiao X Liu Xing X
Journal of molecular cell biology 20221201 8
Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome segregation. In eukaryotic cells, nuclear envelope breakdown (NEBD) is required for proper chromosome segregation. Although a list of mitotic kinases has been implicated in NEBD, how they coordinate their activity to dissolve the nuclear envelope and protein machinery such as nuclear pore complexes was unclear. Here, we identified a regulatory mechanism in which Nup62 is acet ...[more]