Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC9928200 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Wang Runan R Wang Wenliang W Liu Xuan X Wang Huan H Zhang Bin B Li Shuang S Zhang Haining H Yang Jiawei J Zhao Jishun J He Qiuying Q Zhang Jihong J Liu Danping D Hao Liangchun L
Frontiers in oncology 20230131
<i>TP53</i> mutations are associated with poor prognosis in the vast majority of cancers. In this study, we present a pediatric B-cell acute lymphoblastic leukemia (B-ALL) patient carrying a rare <i>TP53</i> c.C275T mutation. This extremely rare mutation affects an amino acid residue located between the TAD domain and the DNA-binding domain of p53. The patient was resistant to most conventional chemotherapy regimens and remained minimal residual disease (MRD)-positive after five rounds of such r ...[more]