Dataset Information

Development and validation of a nomogram for discriminating between benign and malignant breast masses by conventional ultrasound and dual-mode elastography: a multicenter study.

ABSTRACT:

Background

This study developed and validated an ultrasound nomogram based on conventional ultrasound and dual-mode elastography to differentiate breast masses.

Methods

The data of 234 patients were collected before they underwent breast mass puncture or surgery at 4 different centers between 2016 and 2021. Patients were divided into 5 datasets: internal validation and development sets from the same hospital, and external validation sets from the 3 other hospitals. In the development cohort, age and 294 different ultrasound and elastography features were obtained from ultrasound images. Univariate logistic regression and least absolute shrinkage and selection operator (LASSO) regression were used for data reduction and visualization. Multivariable logistic regression analysis was used to develop the prediction model and ultrasound nomogram. Receiver operating characteristic (ROC) curve analysis, calibration curves, integrated discrimination improvement, and the net reclassification index were used to evaluate nomogram performance; decision curve analysis (DCA) and clinical impact curves were used to estimate clinical usefulness.

Results

In the development cohort, margin, posterior features, shape, vascularity, (the mean shear wave elastography value of 1.5 mm surrounding tissues in a breast mass) divided by (the mean shear wave elastography value of the breast mass)-shell mean/A mean1.5(E), (the ratio of strain elastography of adipose tissue near a breast mass) divided by [the ratio of strain elastography of (the breast mass adds the 1.5 mm surrounding tissues in the breast mass)]-B/A'1.5 were selected as predictors in multivariable logistic regression analysis, comprising Model 1. Among the 5 cohorts, Model 1 performed best, with areas under the curve (AUC) of 0.92, 0.84, 0.87, 0.93, and 0.89, respectively. The AUCs were 0.90, 0.82, 0.83, 0.91, and 0.85, respectively, in Model 2 (margin + posterior features + shape + vascularity) and 0.80, 0.76, 0.77, 0.87, and 0.80, respectively, in Model 3 [shell mean/A mean1.5(E) + B/A'1.5].

Conclusions

Our ultrasound nomograms facilitate exposure to the features and visualization of breast cancer. Shell mean/A mean1.5(E), B/A'1.5 integrated with margin, posterior features, shape, and vascularity are superior at identifying breast cancer, and are worthy of further clinical investigation.

SUBMITTER: Yang K

PROVIDER: S-EPMC9929388 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Development and validation of a nomogram for discriminating between benign and malignant breast masses by conventional ultrasound and dual-mode elastography: a multicenter study.

Yang Keen K Ye Xiuqin X Tian Hongtian H Li Qiaoying Q Liu Qinghua Q Li Jingjing J Guo Jinhan J Xu Jinfeng J Dong Fajin F

Quantitative imaging in medicine and surgery 20230111 2

<h4>Background</h4>This study developed and validated an ultrasound nomogram based on conventional ultrasound and dual-mode elastography to differentiate breast masses.<h4>Methods</h4>The data of 234 patients were collected before they underwent breast mass puncture or surgery at 4 different centers between 2016 and 2021. Patients were divided into 5 datasets: internal validation and development sets from the same hospital, and external validation sets from the 3 other hospitals. In the developm ...[more]

PMID: 36819244

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Dataset Information

Development and validation of a nomogram for discriminating between benign and malignant breast masses by conventional ultrasound and dual-mode elastography: a multicenter study.

Background

Methods

Results

Conclusions

Publications

Development and validation of a nomogram for discriminating between benign and malignant breast masses by conventional ultrasound and dual-mode elastography: a multicenter study.

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