Dataset Information

Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.

ABSTRACT: Modern artificial neural networks (ANNs) have long been designed on foundations of mathematics as opposed to their original foundations of biomimicry. However, the structure and function of these modern ANNs are often analogous to real-life biological networks. We propose that the ubiquitous information-theoretic principles underlying the development of ANNs are similar to the principles guiding the macro-evolution of biological networks and that insights gained from one field can be applied to the other. We generate hypotheses on the bow-tie network structure of the Janus kinase - signal transducers and activators of transcription (JAK-STAT) pathway, additionally informed by the evolutionary considerations, and carry out ANN simulation experiments to demonstrate that an increase in the network's input and output complexity does not necessarily require a more complex intermediate layer. This observation should guide novel biomarker discovery-namely, to prioritize sections of the biological networks in which information is most compressed as opposed to biomarkers representing the periphery of the network.

SUBMITTER: Hilliard S

PROVIDER: S-EPMC9929672 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.

Hilliard Seth S Mosoyan Karen K Branciamore Sergio S Gogoshin Grigoriy G Zhang Alvin A Simons Diana L DL Rockne Russell C RC Lee Peter P PP Rodin Andrei S AS

iScience 20230125 2

Modern artificial neural networks (ANNs) have long been designed on foundations of mathematics as opposed to their original foundations of biomimicry. However, the structure and function of these modern ANNs are often analogous to real-life biological networks. We propose that the ubiquitous information-theoretic principles underlying the development of ANNs are similar to the principles guiding the macro-evolution of biological networks and that insights gained from one field can be applied to ...[more]

PMID: 36818303

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Project description:Bow-tie structures were introduced to describe the World Wide Web (WWW): in the direct network in which the nodes are the websites and the edges are the hyperlinks connecting them, the greatest number of nodes takes part to a bow-tie, i.e. a Weakly Connected Component (WCC) composed of 3 main sectors: IN, OUT and SCC. SCC is the main Strongly Connected Component of WCC, i.e. the greatest subgraph in which each node is reachable by any other one. The IN and OUT sectors are the set of nodes not included in SCC that, respectively, can access and are accessible to nodes in SCC. In the WWW, the greatest part of the websites can be found in the SCC, while the search engines belong to IN and the authorities, as Wikipedia, are in OUT. In the analysis of Twitter debate, the recent literature focused on discursive communities, i.e. clusters of accounts interacting among themselves via retweets. In the present work, we studied discursive communities in 8 different thematic Twitter datasets in various languages. Surprisingly, we observed that almost all discursive communities therein display a bow-tie structure during political or societal debates. Instead, they are absent when the argument of the discussion is different as sport events, as in the case of Euro2020 Turkish and Italian datasets. We furthermore analysed the quality of the content created in the various sectors of the different discursive communities, using the domain annotation from the fact-checking website Newsguard: we observe that, when the discursive community is affected by m/disinformation, the content with the lowest quality is the one produced and shared in SCC and, in particular, a strong incidence of low- or non-reputable messages is present in the flow of retweets between the SCC and the OUT sectors. In this sense, in discursive communities affected by m/disinformation, the greatest part of the accounts has access to a great variety of contents, but whose quality is, in general, quite low; such a situation perfectly describes the phenomenon of infodemic, i.e. the access to "an excessive amount of information about a problem, which makes it difficult to identify a solution", according to WHO.

Dataset Information

Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.

Publications

Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.

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