Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez MJ
PROVIDER: S-EPMC9932145 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Rodriguez María Jimena MJ Perrone María Cecilia MC Riggio Marina M Palafox Marta M Salinas Valeria V Elia Andrés A Salgueiro Natali Daiana ND Werbach Andrea Eugenia AE Marks María Paula MP Kauffman Marcelo A MA Vellón Luciano L Serra Violeta V Novaro Virginia V
Scientific reports 20230215 1
Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic strategies to delay disease progression and improve patient survival. Here, we assessed the mechanisms of acquired resistance using T47D and MCF-7 tamoxifen- and palbociclib-resistant cell-line variants in culture and as xenografts, and patient-deri ...[more]