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Measurement of Minute Liquid Volumes of Chiral Molecules Using In-Fiber Polarimetry.

ABSTRACT: We report an optofluidic method that enables to efficiently measure the enantiomeric excess of chiral molecules at low concentrations. The approach is to monitor the optical activity induced by a Kagome-lattice hollow-core photonic crystal fiber filled with a sub-μL volume of chiral compounds. The technique also allows monitoring the enzymatic racemization of R-mandelic acid.

SUBMITTER: Schorn F

PROVIDER: S-EPMC9933876 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Measurement of Minute Liquid Volumes of Chiral Molecules Using In-Fiber Polarimetry.

Schorn Florian F Essert Arabella A Zhong Yu Y Abdullayev Sahib S Castiglione Kathrin K Haumann Marco M Joly Nicolas Y NY

Analytical chemistry 20230131 6

We report an optofluidic method that enables to efficiently measure the enantiomeric excess of chiral molecules at low concentrations. The approach is to monitor the optical activity induced by a Kagome-lattice hollow-core photonic crystal fiber filled with a sub-μL volume of chiral compounds. The technique also allows monitoring the enzymatic racemization of R-mandelic acid. ...[more]

PMID: 36720470

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