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Primary Pleural Angiosarcoma Treated with Nivolumab and Ipilimumab: A Case Report.


ABSTRACT: Primary pleural angiosarcoma (PPA) is a rare and clinically fatal pleural tumor originating from vascular endothelial cells. Herein, we presented the case of a 73-year-old man who was referred to our emergency room with complaints of right chest and back pain for a few days. Chest computed tomography revealed massive pleural effusion and a large mass in the right chest cavity. Thoracoscopic examination demonstrated a large hemorrhagic tumor on the parietal pleura whose pathological analysis indicated PPA. The patient received immunotherapy combined with nivolumab and ipilimumab. A cycle of nivolumab and ipilimumab improved his hemorrhagic anemia and reduced the pleural effusion and tumor size. This treatment outcome suggests that nivolumab and ipilimumab comprise a vital treatment option for PPA.

SUBMITTER: Nakamura M 

PROVIDER: S-EPMC9938394 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature

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Primary Pleural Angiosarcoma Treated with Nivolumab and Ipilimumab: A Case Report.

Nakamura Mikako M   Watanabe Kaoru K   Nishimura Taku T   Yoshida Keishi K   Fukumoto Kento K   Hiyama Noriko N   Masuda Yoshio Y   Morikawa Teppei T   Matsumoto Jun J   Usui Kazuhiro K  

Case reports in oncology 20230101 1


Primary pleural angiosarcoma (PPA) is a rare and clinically fatal pleural tumor originating from vascular endothelial cells. Herein, we presented the case of a 73-year-old man who was referred to our emergency room with complaints of right chest and back pain for a few days. Chest computed tomography revealed massive pleural effusion and a large mass in the right chest cavity. Thoracoscopic examination demonstrated a large hemorrhagic tumor on the parietal pleura whose pathological analysis indi  ...[more]

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