FSH blockade improves cognition in mice with Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Xiong J
PROVIDER: S-EPMC9940301 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
FSH blockade improves cognition in mice with Alzheimer's disease.
Xiong Jing J Kang Seong Su SS Wang Zhihao Z Liu Xia X Kuo Tan-Chun TC Korkmaz Funda F Padilla Ashley A Miyashita Sari S Chan Pokman P Zhang Zhaohui Z Katsel Pavel P Burgess Jocoll J Gumerova Anisa A Ievleva Kseniia K Sant Damini D Yu Shan-Ping SP Muradova Valeriia V Frolinger Tal T Lizneva Daria D Iqbal Jameel J Goosens Ki A KA Gera Sakshi S Rosen Clifford J CJ Haroutunian Vahram V Ryu Vitaly V Yuen Tony T Zaidi Mone M Ye Keqiang K
Nature 20220302 7901
Alzheimer's disease has a higher incidence in older women, with a spike in cognitive decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss during the menopausal transition<sup>1,2</sup>. Inhibiting the action of follicle-stimulating hormone (FSH) reduces body fat, enhances thermogenesis, increases bone mass and lowers serum cholesterol in mice<sup>3-7</sup>. Here we show that FSH acts directly on hippocampal and cortical neurons to accelerate amyloid-β and Ta ...[more]
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