Dataset Information

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by ¹⁸F-FDG PET in patients with a recent ischemic stroke.

ABSTRACT:

Background

¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence.

Aim

Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation.

Methods

A prospective study was conducted among adult patients with recent (< 7 days) anterior circulation ischemic stroke and at least one atherosclerotic plaque in the ipsilateral internal carotid artery. Patients underwent an early (< 15 days from inclusion) ¹⁸F-FDG PET, and the maximum standardized uptake value (SUVmax) within the plaque was measured. sLRP1 levels were measured in plasma samples by ELISA. The association of sLRP1 with SUVmax was assessed using bivariate and multivariable linear regression analyses. Hazard ratios (HR) were estimated with Cox regression to evaluate the association between circulating sLRP1 and stroke recurrence.

Results

The study was conducted with 64 participants, of which 57.8% had ≥ 50% carotid stenosis. The multivariable linear and logistic regression analyses showed that sLRP1 was independently associated with (i) SUVmax within the plaque (β = 0.159, 95% CI 0.062-0.257, p = 0.002) and (ii) a probability of presenting SUVmax ≥ 2.85 g/mL (OR = 1.31, 95% CI 1.00-1.01, p = 0.046), respectively. Participants with stroke recurrence showed higher sLRP1 levels at baseline [6447 ng/mL (4897-11163) vs. 3713 ng/mL (2793-4730); p = 0.018].

Conclusions

sLRP1 was independently associated with carotid plaque inflammation as measured by ¹⁸F-FDG PET in patients with recent ischemic stroke and carotid atherosclerosis.

SUBMITTER: Garcia E

PROVIDER: S-EPMC9940334 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by <sup>18</sup>F-FDG PET in patients with a recent ischemic stroke.

Garcia Eduardo E Camps-Renom Pol P Puig Núria N Fernández-Leon Alejandro A Aguilera-Simón Ana A Benitez-Amaro Aleyda A Solé Arnau A Vilades David D Sanchez-Quesada José Luis JL Martí-Fàbregas Joan J Jiménez-Xarrié Elena E Benitez Sonia S Llorente-Cortés Vicenta V Llorente-Cortés Vicenta V

Journal of translational medicine 20230219 1

<h4>Background</h4><sup>18</sup>F-fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence.<h4>Aim</h4>Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation.<h4>Methods</h4>A prospective study was conducted among adult patients with recent (< 7 days) anterior circulation ischemic stroke and at least one athero ...[more]

PMID: 36805772

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Project description:PurposeTumor voxel dose-response matrix (DRM) can be quantified using feedback from serial FDG-PET/CT imaging acquired during radiotherapy. This study investigated the dynamic characteristics and the predictive capability of DRM.MethodsFDG-PET/CT images were acquired before and weekly during standard chemoradiotherapy with the treatment dose 2 Gy × 35 from 31 head and neck cancer patients. For each patient, deformable image registration was performed between the pretreatment/baseline PET/CT image and each weekly PET/CT image. Tumor voxel DRM was derived using linear regression on the logarithm of the weekly standard uptake value (SUV) ratios for each tumor voxel, such as SUV measured at a dose level normalized to the baseline SUV0. The dynamic characteristics were evaluated by comparing the DRMi estimated using a single feedback image acquired at the ith treatment week (i = 1, 2, 3, or 4) to the DRM estimated using the last feedback image for each patient. The predictive capability of the DRM estimated using 1 or 2 feedback images was evaluated using the receiver operating characteristic test with respect to the treatment outcome of tumor local-regional control or failure.ResultsThe mean ± SD of tumor voxel SUV measured at the pretreatment and the 1st, 2nd, 3rd, 4th, and last treatment weeks was 6.76 ± 3.69, 5.72 ± 3.43, 3.85 ± 2.22, 3.27 ± 2.25, 2.5 ± 1.79, and 2.23 ± 1.27, respectively. The deviations between the DRMi estimated using the single feedback image obtained at the ith week and the last feedback image were 0.86 ± 4.87, -0.06 ± 0.3, -0.09 ± 0.17, and -0.09 ± 0.12 for DRM1, DRM2, DRM3, and DRM4, respectively. The predictive capability of DRM3 and DRM4 was significant (p < 0.001). The area under the curve (AUC) was increased with the increase in treatment dose level. The DRMs constructed using the single feedback image achieved an AUC of 0.86~1. The AUC was slightly improved to 0.94~1 for the DRMs estimated using 2 feedback images.ConclusionTumor voxel metabolic activity measured using FDG-PET/CT fluctuated noticeably during the first 2 treatment weeks and obtained a stabilized reduction rate thereafter. Tumor voxel DRM constructed using a single FDG-PET/CT feedback image after the 2nd treatment week (>20 Gy) has a good predictive capability. The predictive capability improved continuously using a later feedback image and marginally improved when two feedback images were applied.

Dataset Information

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by ¹⁸F-FDG PET in patients with a recent ischemic stroke.

Background

Aim

Methods

Results

Conclusions

Publications

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by <sup>18</sup>F-FDG PET in patients with a recent ischemic stroke.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke.

Background

Aim

Methods

Results

Conclusions

Publications

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by &lt;sup&gt;18&lt;/sup&gt;F-FDG PET in patients with a recent ischemic stroke.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by ¹⁸F-FDG PET in patients with a recent ischemic stroke.

Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by <sup>18</sup>F-FDG PET in patients with a recent ischemic stroke.