Ontology highlight
ABSTRACT:
SUBMITTER: Angeli A
PROVIDER: S-EPMC9940851 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Angeli Andrea A Velluzzi Alice A Selleri Silvia S Capasso Clemente C Spadini Costanza C Iannarelli Mattia M Cabassi Clotilde S CS Carta Fabrizio F Supuran Claudiu T CT
ACS infectious diseases 20220819 9
Fungal promoted infections are becoming a severe health global emergency due to drug-resistant phenomena and zoonosis. This work investigated compounds bearing acyl-/selenoureido moieties and primary/secondary sulfonamide groups as novel antifungal agents acting through organism-directed selenium toxicity and inhibition of the newly emergent therapeutic target, the Carbonic Anhydrases (CAs; EC 4.2.1.1). Reported data clearly indicate that seleno-containing scaffolds with respect to the standard- ...[more]