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Slice & Dice: nested spin-lattice relaxation measurements.

ABSTRACT: Spin-lattice relaxation rate (R₁) measurements are commonly used to characterize protein dynamics. However, the time needed to collect the data can be quite long due to long relaxation times of the low-gamma nuclei, especially in the solid state. We present a method to collect backbone heavy atom relaxation data by nesting the collection of datasets in the solid state. This method results in a factor of 2 to 2.5 times faster data acquisition for backbone R₁ relaxation data for the ¹³C and ¹⁵N sites of proteins.

SUBMITTER: Franks WT

PROVIDER: S-EPMC9945929 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Slice & Dice: nested spin-lattice relaxation measurements.

Franks W Trent WT Tognetti Jacqueline J Lewandowski Józef R JR

Physical chemistry chemical physics : PCCP 20230222 8

Spin-lattice relaxation rate (R1) measurements are commonly used to characterize protein dynamics. However, the time needed to collect the data can be quite long due to long relaxation times of the low-gamma nuclei, especially in the solid state. We present a method to collect backbone heavy atom relaxation data by nesting the collection of datasets in the solid state. This method results in a factor of 2 to 2.5 times faster data acquisition for backbone R1 re ...[more]

PMID: 36281524

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