Ontology highlight
ABSTRACT: One sentence summary
Silica induces the alveolar epithelium to reprogram recruited and resident pulmonary myeloid cells to become osteoclasts that contribute to pulmonary fibrosis.
SUBMITTER: Hasegawa Y
PROVIDER: S-EPMC9949165 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20230218
The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored the mechanisms of silica-induced pulmonary fibrosis in a mouse model using multiple modalities including whole-lung single-nucleus RNA sequencing. These analyses revealed that in addition to pulmonary inflammation and fibrosis, intratracheal silica challenge induced osteoclast-like differentiation of alveolar macrophages and recruited mo ...[more]