Dataset Information

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.

ABSTRACT:

Background

The rate of tuberculosis (TB) infection among the prison population (PP) in Brazil is 28 times higher than that in the general population, and prison environment favors the spread of TB.

Objective

To describe TB transmission dynamics and drug resistance profiles in PP using whole-genome sequencing (WGS).

Methods

This was a retrospective study of Mycobacterium tuberculosis cultivated from people incarcerated in 55 prisons between 2016 and 2019; only one isolate per prisoner was included. Information about movement from one prison to another was tracked. Clinical information was collected, and WGS was performed on isolates obtained at the time of TB diagnosis.

Results

Among 134 prisoners included in the study, we detected 16 clusters with a total of 58 (43%) cases of M. tuberculosis. Clusters ranged from two to seven isolates with five or fewer single nucleotide polymorphism (SNP) differences, suggesting a recent transmission. Six (4.4%) isolates were resistant to at least one anti-TB drug. Two of these clustered together and showed resistance to rifampicin, isoniazid, and fluoroquinolones, with 100% concordance between WGS and phenotypic drug-susceptibility testing. Prisoners with clustered isolates had a high amount of movement between prisons (two to eight moves) during the study period.

Conclusions

WGS demonstrated the recent transmission of TB within prisons in Brazil. The high movement among prisoners seems to be related to the transmission of the same M. tuberculosis strain within the prison system. Screening for TB before and after the movement of prisoners using rapid molecular tests could play a role in reducing transmission.

SUBMITTER: Anselmo LMP

PROVIDER: S-EPMC9957134 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.

Anselmo Lívia Maria Pala LMP Gallo Juliana Failde JF Pinhata Juliana Maira Watanabe JMW Peronni Kamila Chagas KC Silva Junior Wilson Araújo da WAD Ruy Patricia de Cássia PC Conceição Emilyn Costa EC Dippenaar Anzaan A Warren Robin Mark RM Monroe Aline Aparecida AA Oliveira Rosangela Siqueira RS Bollela Valdes Roberto VR

Revista da Sociedade Brasileira de Medicina Tropical 20230220

<h4>Background</h4>The rate of tuberculosis (TB) infection among the prison population (PP) in Brazil is 28 times higher than that in the general population, and prison environment favors the spread of TB.<h4>Objective</h4>To describe TB transmission dynamics and drug resistance profiles in PP using whole-genome sequencing (WGS).<h4>Methods</h4>This was a retrospective study of Mycobacterium tuberculosis cultivated from people incarcerated in 55 prisons between 2016 and 2019; only one isolate pe ...[more]

PMID: 36820651

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Dataset Information

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.

Background

Objective

Methods

Results

Conclusions

Publications

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.

Similar Datasets

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