Gut Microbiota and Metabolome Changes in Three Pulmonary Hypertension Rat Models.
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ABSTRACT:
SUBMITTER: Luo L
PROVIDER: S-EPMC9959815 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Gut Microbiota and Metabolome Changes in Three Pulmonary Hypertension Rat Models.
Luo Lingjie L Yin Haoyang H Gou Deming D
Microorganisms 20230213 2
Dysbiosis of the gut microbiota and metabolites is found in both pulmonary hypertension patients and pulmonary hypertension rodent models. However, the exact changes in gut microbiota during the development of pulmonary hypertension is unclear. The function of the gut microbiota is also ambiguous. Here, this study showed that the gut microbiota was disrupted in rats with hypoxia (Hyp)-, hypoxia/Sugen5416 (HySu)-, and monocrotaline (MCT)-induced pulmonary hypertension. The gut microbiota is dynam ...[more]
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