Ontology highlight
ABSTRACT:
SUBMITTER: Dinis P
PROVIDER: S-EPMC9976750 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Dinis Pedro P Tirkkonen Heli H Wandi Benjamin Nji BN Siitonen Vilja V Niemi Jarmo J Grocholski Thadée T Metsä-Ketelä Mikko M
PNAS nexus 20230228 2
<i>Streptomyces</i> soil bacteria produce hundreds of anthracycline anticancer agents with a relatively conserved set of genes. This diversity depends on the rapid evolution of biosynthetic enzymes to acquire novel functionalities. Previous work has identified <i>S</i>-adenosyl-l-methionine-dependent methyltransferase-like proteins that catalyze 4-O-methylation, 10-decarboxylation, or 10-hydroxylation, with additional differences in substrate specificities. Here we focused on four protein region ...[more]