Dataset Information

Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy.

ABSTRACT:

Background

Liquid biopsy and Integrative Genomic Profiling (IGP) are yet to be implemented into routine Radiation Oncology. Here we assess the utility of germline, tumour and circulating cell-free DNA-based genomic analyses for the clinical management of early-stage and oligometastatic cancer patients treated by precision radiotherapy.

Methods

We performed germline, tissue- and liquid biopsy NGS panels on 50 early-stage/oligometastatic cancer patients undergoing radiotherapy. We also monitored ctDNA variants in serial liquid biopsies collected during radiotherapy and follow-up and evaluated the clinical utility of such comprehensive approach.

Results

The integration of different genomic studies revealed that only 1/3 of the liquid biopsy variants are of tumour origin. Altogether, 55 tumour variants (affecting 3/4 of the patients) were considered potentially actionable (for treatment and prognosis), whereas potential follow-up biomarkers were identified in all cases. Germline cancer-predisposing variants were present in three patients, which would have not been eligible for hereditary cancer testing according to clinical guidelines. The presence of detectable ctDNA variants before radiotherapy was associated with progression-free survival both in oligometastatic patients and in those with early-stage.

Conclusions

IGP provides both valuable and actionable information for personalised decision-making in Radiation Oncology.

SUBMITTER: Cifuentes GA

PROVIDER: S-EPMC9977775 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy.

Cifuentes Guadalupe A GA Santiago Adrián A Méndez Blanco Lucía L Fueyo María M López Martínez Esther E Soria Raquel R Martín López Irene I Cucarella Beltrán Pepa P Pardo-Coto Pablo P Rodriguez-Rubi David D Urquilla Karla K Durán Noelia S NS Álvarez Rebeca R Lago Claudia G CG Otero Andrea A Diñeiro Marta M Capín Raquel R Cadiñanos Juan J Cabanillas Rubén R

British journal of cancer 20221222 5

<h4>Background</h4>Liquid biopsy and Integrative Genomic Profiling (IGP) are yet to be implemented into routine Radiation Oncology. Here we assess the utility of germline, tumour and circulating cell-free DNA-based genomic analyses for the clinical management of early-stage and oligometastatic cancer patients treated by precision radiotherapy.<h4>Methods</h4>We performed germline, tissue- and liquid biopsy NGS panels on 50 early-stage/oligometastatic cancer patients undergoing radiotherapy. We a ...[more]

PMID: 36550207

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Dataset Information

Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy.

Background

Methods

Results

Conclusions

Publications

Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy.

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