Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae.
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ABSTRACT:
SUBMITTER: Vik A
PROVIDER: S-EPMC99787 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Publications
Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae.
Molecular and cellular biology 20011001 19
Sterol levels affect the expression of many genes in yeast and humans. We found that the paralogous transcription factors Upc2p and Ecm22p of yeast were sterol regulatory element (SRE) binding proteins (SREBPs) responsible for regulating transcription of the sterol biosynthetic genes ERG2 and ERG3. We defined a 7-bp SRE common to these and other genes, including many genes involved in sterol biosynthesis. Upc2p and Ecm22p activated ERG2 expression by binding directly to this element in the ERG2 ...[more]
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