Ontology highlight
ABSTRACT:
SUBMITTER: Haukedal H
PROVIDER: S-EPMC9978754 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Haukedal Henriette H Corsi Giulia I GI Gadekar Veerendra P VP Doncheva Nadezhda T NT Kedia Shekhar S de Haan Noortje N Chandrasekaran Abinaya A Jensen Pia P Schiønning Pernille P Vallin Sarah S Marlet Frederik Ravnkilde FR Poon Anna A Pires Carlota C Agha Fawzi Khoder FK Wandall Hans H HH Cirera Susanna S Simonsen Anja Hviid AH Nielsen Troels Tolstrup TT Nielsen Jørgen Erik JE Hyttel Poul P Muddashetty Ravi R Aldana Blanca I BI Gorodkin Jan J Nair Deepak D Meyer Morten M Larsen Martin Røssel MR Freude Kristine K
Frontiers in neuroscience 20230216
Alzheimer's disease (AD) is the most common cause of dementia, with no current cure. Consequently, alternative approaches focusing on early pathological events in specific neuronal populations, besides targeting the well-studied amyloid beta (Aβ) accumulations and Tau tangles, are needed. In this study, we have investigated disease phenotypes specific to glutamatergic forebrain neurons and mapped the timeline of their occurrence, by implementing familial and sporadic human induced pluripotent st ...[more]