Ontology highlight
ABSTRACT:
SUBMITTER: Thornburg ZR
PROVIDER: S-EPMC9985924 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Thornburg Zane R ZR Bianchi David M DM Brier Troy A TA Gilbert Benjamin R BR Earnest Tyler M TM Melo Marcelo C R MCR Safronova Nataliya N Sáenz James P JP Cook András T AT Wise Kim S KS Hutchison Clyde A CA Smith Hamilton O HO Glass John I JI Luthey-Schulten Zaida Z
Cell 20220101 2
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell with a reduced genome of 493 genes that has retained few regulatory proteins or small RNAs. Cryo-electron tomograms provide the cell geometry and ribosome distributions. Time-dependent behaviors of concentrations and reaction fluxes from stochastic-deterministic simulations over a cell cycle reveal how the cell balances demands of its metabolism, genetic information processes, and growth, and offer insight ...[more]