Ontology highlight
ABSTRACT:
SUBMITTER: Zeng FL
PROVIDER: S-EPMC9986080 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Zeng Fan-Lian FL Wang Xiao-Yan XY Hu Ya-Wen YW Wang Zhen Z Li Ya Y Hu Jing J Yu Jia-Dong JD Zhou Pei P Teng Xiu X Zhou Hong H Zheng Hua-Ping HP Zhao Fu-Lei FL Gu Lin-Na LN Yue Cheng-Cheng CC Chen Shu-Wen SW Cheng Juan J Hao Yan Y Zhao Qi-Xiang QX Zhang Chen C Zou Song S Hu Zhong-Lan ZL Wei Xiao-Qiong XQ Liu Xiao X Li Guo-Lin GL Huang Nong-Yu NY Wu Wen-Ling WL Zhou Yi-Fan YF Li Wei W Cui Kaijun K Li Jiong J
MedComm 20230305 2
Interleukin 37 (IL-37), a member of the IL-1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL-37 in skin cancer remain unclear. Here, we report that IL-37b-transgenic mice (IL-37tg) treated with the carcinogenic 7,12-dimethylbenzoanthracene (DMBA)/12-o-tetradecylphorbol-13-acetate (TPA) exhibited enhanced skin cancer and increased tumor burden in the skin by inhibiting the func ...[more]