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[Advances of Immunotherapy Resistance and Coping Strategies  in Non-small Cell Lung Cancer].

ABSTRACT: Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvironment. Considering the mechanisms of immune resistance are not yet fully understood and the efficacy of standard chemotherapy regimens is limited, more effective coping strategies based on resistance mechanisms are urgently needed. In this review, we intend to summarize the known mechanisms of immune resistance and feasible strategies, so as to provide a foundation for clinicians to develop more individualized and precise regimens and finally improve patients' prognosis. .

SUBMITTER: Jing Y

PROVIDER: S-EPMC9987066 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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[Advances of Immunotherapy Resistance and Coping Strategies  in Non-small Cell Lung Cancer].

Jing Yawan Y Zeng Hao H Cheng Ruixin R Tian Panwen P Li Yalun Y

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20230101 1

Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvironment. Considering the mechanisms of immune resistance are not yet fully understood and the efficacy of standard chemotherapy regimens is limited, more effective coping strategies based on resistanc ...[more]

PMID: 36792083

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