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Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones.

ABSTRACT: Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones have been established for the synthesis of enantioenriched γ-hydroxybutyric acid derivatives in the presence of Cu(ii)/trisoxazoline catalyst. These reactions offered the desired products in 70% to 93% yields with 79% to 99% enantiomeric excesses.

SUBMITTER: Zhang D

PROVIDER: S-EPMC9990749 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones.

Zhang Dongxin D Chen Lvjia L Deng Huiqing H Zhang Ying Y Cheng Qihang Q Zhang Qian-Feng QF

RSC advances 20230307 11

Asymmetric ring-opening reactions of donor-acceptor cyclopropanes with 1,3-cyclodiones have been established for the synthesis of enantioenriched γ-hydroxybutyric acid derivatives in the presence of Cu(ii)/trisoxazoline catalyst. These reactions offered the desired products in 70% to 93% yields with 79% to 99% enantiomeric excesses. ...[more]

PMID: 36895764

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