Ontology highlight
ABSTRACT:
SUBMITTER: Brown A
PROVIDER: S-EPMC9992519 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Brown Anthony A Pan Qingfei Q Fan Li L Indersie Emilie E Tian Cheng C Timchenko Nikolai N Li Liyuan L Hansen Baranda S BS Tan Haiyan H Lu Meifen M Peng Junmin J Pruett-Miller Shondra M SM Yu Jiyang J Yu Jiyang J Cairo Stefano S Zhu Liqin L
Communications biology 20230308 1
Prognosis of children with high-risk hepatoblastoma (HB), the most common pediatric liver cancer, remains poor. In this study, we found ribonucleotide reductase (RNR) subunit M2 (RRM2) was one of the key genes supporting cell proliferation in high-risk HB. While standard chemotherapies could effectively suppress RRM2 in HB cells, they induced a significant upregulation of the other RNR M2 subunit, RRM2B. Computational analysis revealed distinct signaling networks RRM2 and RRM2B were involved in ...[more]