Ontology highlight
ABSTRACT:
SUBMITTER: Tourriere H
PROVIDER: S-EPMC99945 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Tourrière H H Gallouzi I E IE Chebli K K Capony J P JP Mouaikel J J van der Geer P P Tazi J J
Molecular and cellular biology 20011101 22
Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not quiescent cells. G3BP exclusively cleaves between cytosine and adenine (CA) after a specific interaction with RNA through the carboxyl-terminal RRM-type RNA binding motif. Accordingly, G3BP is tightly associated with a subset of poly(A)(+) mRNAs containing its high-affinity binding sequence, such as the c- ...[more]