Ontology highlight
ABSTRACT:
SUBMITTER: Nagaoka T
PROVIDER: S-EPMC9995352 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Nagaoka Tadahiro T Katsuno Tatsuya T Fujimura Kyoka K Tsuchida Kunihiro K Kishi Masashi M
Scientific reports 20230308 1
Although the core constituents of the Wnt/planar cell polarity (PCP) signaling have been extensively studied, their downstream molecules and protein-protein interactions have not yet been fully elucidated. Here, we show genetic and molecular evidence that the PCP factor, Vangl2, functionally interacts with the cell-cell adhesion molecule, N-cadherin (also known as Cdh2), for typical PCP-dependent neural development. Vangl2 and N-cadherin physically interact in the neural plates undergoing conver ...[more]