Unknown

Dataset Information

0

Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample.


ABSTRACT: We characterized the additive contribution of cerebrovascular biomarkers to amyloid and neurodegeneration biomarkers (AV(N)) when modeling prospective, longitudinal cognitive trajectories within 3 major racial/ethnic groups. Participants (n = 172; age = 69-96 years; 62% women; 31%/49%/20% Non-Hispanic White/Non-Hispanic Black/Hispanic) from the Washington Heights-Inwood Columbia Aging Project were assessed for amyloid (Florbetaben PET), neurodegeneration (cortical thickness, hippocampal volume), and cerebrovascular disease (white matter hyperintensity (WMH), infarcts). Neuropsychological assessments occurred every 2.3 ± 0.6 years for up to 6 visits (follow-up time: 4.2 ± 3.2 years). Linear mixed-effects models were stratified by race/ethnicity groups. Higher amyloid was associated with faster memory decline in all 3 racial/ethnic groups, but was related to faster cognitive decline beyond memory in minoritized racial/ethnic groups. Higher WMH was associated with faster language, processing speed/executive function, and visuospatial ability decline in Non-Hispanic Black participants, while infarcts were associated with faster processing speed/executive function decline in Non-Hispanic White participants. Complementary information from AD, neurodegenerative, and cerebrovascular biomarkers explain decline in multiple cognitive domains, which may differ within each racial/ethnic group. Importantly, treatment strategies exist to minimize vascular contributions to cognitive decline.

SUBMITTER: Lao PJ 

PROVIDER: S-EPMC9997572 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample.

Lao Patrick J PJ   Boehme Amelia K AK   Morales Clarissa C   Laing Krystal K KK   Chesebro Anthony A   Igwe Kay C KC   Gutierrez Jose J   Gu Yian Y   Stern Yaakov Y   Schupf Nicole N   Manly Jennifer J JJ   Mayeux Richard R   Brickman Adam M AM  

Neurobiology of aging 20220513


We characterized the additive contribution of cerebrovascular biomarkers to amyloid and neurodegeneration biomarkers (AV(N)) when modeling prospective, longitudinal cognitive trajectories within 3 major racial/ethnic groups. Participants (n = 172; age = 69-96 years; 62% women; 31%/49%/20% Non-Hispanic White/Non-Hispanic Black/Hispanic) from the Washington Heights-Inwood Columbia Aging Project were assessed for amyloid (Florbetaben PET), neurodegeneration (cortical thickness, hippocampal volume),  ...[more]

Similar Datasets

| S-EPMC8719430 | biostudies-literature
| S-EPMC10840752 | biostudies-literature
| S-EPMC10526697 | biostudies-literature
| S-EPMC5741524 | biostudies-other
| S-EPMC5558197 | biostudies-other
| S-EPMC9484040 | biostudies-literature
| S-EPMC11866458 | biostudies-literature
| S-EPMC6220834 | biostudies-literature
| S-EPMC7558806 | biostudies-literature
| S-EPMC9664371 | biostudies-literature