Low-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure.
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ABSTRACT:
SUBMITTER: Bujo S
PROVIDER: S-EPMC9998649 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Low-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure.
Bujo Satoshi S Toko Haruhiro H Ito Kaoru K Koyama Satoshi S Ishizuka Masato M Umei Masahiko M Yanagisawa-Murakami Haruka H Guo Jiaxi J Zhai Bowen B Zhao Chunxia C Kishikawa Risa R Takeda Norifumi N Tsushima Kensuke K Ikeda Yuichi Y Takimoto Eiki E Morita Hiroyuki H Harada Mutsuo M Komuro Issei I
Scientific reports 20230309 1
Cardiovascular disease (CVD) is a global health burden in the world. Although low-carbohydrate diets (LCDs) have beneficial effects on CVD risk, their preventive effects remain elusive. We investigated whether LCDs ameliorate heart failure (HF) using a murine model of pressure overload. LCD with plant-derived fat (LCD-P) ameliorated HF progression, whereas LCD with animal-derived fat (LCD-A) aggravated inflammation and cardiac dysfunction. In the hearts of LCD-P-fed mice but not LCD-A, fatty aci ...[more]
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