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SBF-SEM of ring-stage malaria parasite infected red blood cell

ABSTRACT:

SUBMITTER: Miako Sakaguchi

PROVIDER: EMPIAR-10052 | biostudies-other |

REPOSITORIES: biostudies-other

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Three-dimensional analysis of morphological changes in the malaria parasite infected red blood cell by serial block-face scanning electron microscopy.

Sakaguchi Miako M Miyazaki Naoyuki N Fujioka Hisashi H Kaneko Osamu O Murata Kazuyoshi K

Journal of structural biology 20160107 3

The human malaria parasite, Plasmodium falciparum, exhibits morphological changes during the blood stage cycle in vertebrate hosts. Here, we used serial block-face scanning electron microscopy (SBF-SEM) to visualize the entire structures of P. falciparum-infected red blood cells (iRBCs) and to examine their morphological and volumetric changes at different stages. During developmental stages, the parasite forms Maurer's clefts and vesicles in the iRBC cytoplasm and knobs on the iRBC surface, and ...[more]

PMID: 26772147

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