Lambda excision HJ intermediate
Ontology highlight
ABSTRACT:
SUBMITTER: Nikolaus Grigorieff
PROVIDER: EMPIAR-10065 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction.
Laxmikanthan Gurunathan G Xu Chen C Brilot Axel F AF Warren David D Steele Lindsay L Seah Nicole N Tong Wenjun W Grigorieff Nikolaus N Landy Arthur A Van Duyne Gregory D GD
eLife 20160525
The molecular machinery responsible for DNA expression, recombination, and compaction has been difficult to visualize as functionally complete entities due to their combinatorial and structural complexity. We report here the structure of the intact functional assembly responsible for regulating and executing a site-specific DNA recombination reaction. The assembly is a 240-bp Holliday junction (HJ) bound specifically by 11 protein subunits. This higher-order complex is a key intermediate in the ...[more]
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