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Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin


ABSTRACT:

SUBMITTER: Joe Atherton 

PROVIDER: EMPIAR-10071 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.

Vemu Annapurna A   Atherton Joseph J   Spector Jeffrey O JO   Szyk Agnieszka A   Moores Carolyn A CA   Roll-Mecak Antonina A  

The Journal of biological chemistry 20160425 25


Microtubules are polymers that cycle stochastically between polymerization and depolymerization, i.e. they exhibit "dynamic instability." This behavior is crucial for cell division, motility, and differentiation. Although studies in the last decade have made fundamental breakthroughs in our understanding of how cellular effectors modulate microtubule dynamics, analysis of the relationship between tubulin sequence, structure, and dynamics has been held back by a lack of dynamics measurements with  ...[more]

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