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The pathway to GTPase activation of elongation factor SelB on the ribosome


ABSTRACT:

SUBMITTER: Niels Fischer 

PROVIDER: EMPIAR-10077 | biostudies-other |

REPOSITORIES: biostudies-other

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In all domains of life, selenocysteine (Sec) is delivered to the ribosome by selenocysteine-specific tRNA (tRNA<sup>Sec</sup>) with the help of a specialized translation factor, SelB in bacteria. Sec-tRNA<sup>Sec</sup> recodes a UGA stop codon next to a downstream mRNA stem-loop. Here we present the structures of six intermediates on the pathway of UGA recoding in Escherichia coli by single-particle cryo-electron microscopy. The structures explain the specificity of Sec-tRNA<sup>Sec</sup> bindin  ...[more]

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2019-07-03 | PXD014436 | Pride