Structure of an ion channel in nano disc
Ontology highlight
ABSTRACT:
SUBMITTER: Yifan Cheng
PROVIDER: EMPIAR-10093 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Jin Peng P Bulkley David D Guo Yanmeng Y Zhang Wei W Guo Zhenhao Z Huynh Walter W Wu Shenping S Meltzer Shan S Cheng Tong T Jan Lily Yeh LY Jan Yuh-Nung YN Cheng Yifan Y
Nature 20170626 7661
Mechanosensory transduction for senses such as proprioception, touch, balance, acceleration, hearing and pain relies on mechanotransduction channels, which convert mechanical stimuli into electrical signals in specialized sensory cells. How force gates mechanotransduction channels is a central question in the field, for which there are two major models. One is the membrane-tension model: force applied to the membrane generates a change in membrane tension that is sufficient to gate the channel, ...[more]
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