Cryo-EM structure of Hrd1 and Hrd3 complex
Ontology highlight
ABSTRACT:
SUBMITTER: Maofu Liao
PROVIDER: EMPIAR-10099 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.
Schoebel Stefan S Mi Wei W Stein Alexander A Ovchinnikov Sergey S Pavlovicz Ryan R DiMaio Frank F Baker David D Chambers Melissa G MG Su Huayou H Li Dongsheng D Rapoport Tom A TA Liao Maofu M
Nature 20170706 7667
Misfolded endoplasmic reticulum proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the membrane, and degraded by the proteasome-a pathway termed endoplasmic reticulum-associated protein degradation (ERAD). Proteins with misfolded domains in the endoplasmic reticulum lumen or membrane are discarded through the ERAD-L and ERAD-M pathways, respectively. In Saccharomyces cerevisiae, both pathways require the ubiquitin ligase Hrd1, ...[more]
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