Dataset Information
Cryo electron microscopy micrographs of yeast Exocyst complex
Ontology highlight
ABSTRACT:
SUBMITTER: Hong-Wei Wang
PROVIDER: EMPIAR-10206 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the exocyst complex.
Nature structural & molecular biology 20180115 2
The exocyst is an evolutionarily conserved octameric protein complex that mediates the tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis and is implicated in many cellular processes such as cell polarization, cytokinesis, ciliogenesis and tumor invasion. Using cryo-EM and chemical cross-linking MS (CXMS), we solved the structure of the Saccharomyces cerevisiae exocyst complex at an average resolution of 4.4 Å. Our model revealed the architecture of the exocyst a ...[more]