Ontology highlight
ABSTRACT:
SUBMITTER: Janette Bernadette Myers
PROVIDER: EMPIAR-10212 | biostudies-other |
REPOSITORIES: biostudies-other
Myers Janette B JB Haddad Bassam G BG O'Neill Susan E SE Chorev Dror S DS Yoshioka Craig C CC Robinson Carol V CV Zuckerman Daniel M DM Reichow Steve L SL
Nature 20181212 7736
Gap junctions establish direct pathways for cell-to-cell communication through the assembly of twelve connexin subunits that form intercellular channels connecting neighbouring cells. Co-assembly of different connexin isoforms produces channels with unique properties and enables communication across cell types. Here we used single-particle cryo-electron microscopy to investigate the structural basis of connexin co-assembly in native lens gap junction channels composed of connexin 46 and connexin ...[more]