Ontology highlight
ABSTRACT:
SUBMITTER: Lu Gan
PROVIDER: EMPIAR-10227 | biostudies-other |
REPOSITORIES: biostudies-other
Gan Lu L Ng Cai Tong CT Chen Chen C Cai Shujun S
GigaScience 20190601 6
<h4>Background</h4>Cells are powered by a large set of macromolecular complexes, which work together in a crowded environment. The in situ mechanisms of these complexes are unclear because their 3D distribution, organization, and interactions are largely unknown. Electron cryotomography (cryo-ET) can address these knowledge gaps because it produces cryotomograms-3D images that reveal biological structure at ∼4-nm resolution. Cryo-ET uses no fixation, dehydration, staining, or plastic embedment, ...[more]