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Cryo electron microscopy of tau filaments from sporadic Alzheimer's disease brain

ABSTRACT:

SUBMITTER: Sjors Scheres

PROVIDER: EMPIAR-10230 | biostudies-other |

REPOSITORIES: biostudies-other

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Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.

Falcon Benjamin B Zhang Wenjuan W Schweighauser Manuel M Murzin Alexey G AG Vidal Ruben R Garringer Holly J HJ Ghetti Bernardino B Scheres Sjors H W SHW Goedert Michel M

Acta neuropathologica 20181001 5

The ordered assembly of tau protein into abnormal filaments is a defining characteristic of Alzheimer's disease (AD) and other neurodegenerative disorders. It is not known if the structures of tau filaments vary within, or between, the brains of individuals with AD. We used a combination of electron cryo-microscopy (cryo-EM) and immuno-gold negative-stain electron microscopy (immuno-EM) to determine the structures of paired helical filaments (PHFs) and straight filaments (SFs) from the frontal c ...[more]

PMID: 30276465

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