Dataset Information
Cryo electron microscopy of tau filaments from sporadic Alzheimer's disease brain
Ontology highlight
ABSTRACT:
SUBMITTER: Sjors Scheres
PROVIDER: EMPIAR-10230 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta neuropathologica 20181001 5
The ordered assembly of tau protein into abnormal filaments is a defining characteristic of Alzheimer's disease (AD) and other neurodegenerative disorders. It is not known if the structures of tau filaments vary within, or between, the brains of individuals with AD. We used a combination of electron cryo-microscopy (cryo-EM) and immuno-gold negative-stain electron microscopy (immuno-EM) to determine the structures of paired helical filaments (PHFs) and straight filaments (SFs) from the frontal c ...[more]