AfTMEM16/nanodisc complex in the absence of Ca2+
Ontology highlight
ABSTRACT:
SUBMITTER: Alessio Accardi
PROVIDER: EMPIAR-10241 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis of Ca<sup>2+</sup>-dependent activation and lipid transport by a TMEM16 scramblase.
Falzone Maria E ME Rheinberger Jan J Lee Byoung-Cheol BC Peyear Thasin T Sasset Linda L Raczkowski Ashleigh M AM Eng Edward T ET Di Lorenzo Annarita A Andersen Olaf S OS Nimigean Crina M CM Accardi Alessio A
eLife 20190116
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, an important step in extracellular signaling networks controlling processes such as apoptosis, blood coagulation, membrane fusion and repair. Several TMEM16 family members have been identified as Ca<su ...[more]
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