Dataset Information
Cryo-EM structure of TRPV5 full length in nanodisc
Ontology highlight
ABSTRACT:
SUBMITTER: Shangyu Dang
PROVIDER: EMPIAR-10254 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insight into TRPV5 channel function and modulation.
Proceedings of the National Academy of Sciences of the United States of America 20190411 18
TRPV5 (transient receptor potential vanilloid 5) is a unique calcium-selective TRP channel essential for calcium homeostasis. Unlike other TRPV channels, TRPV5 and its close homolog, TRPV6, do not exhibit thermosensitivity or ligand-dependent activation but are constitutively open at physiological membrane potentials and modulated by calmodulin (CaM) in a calcium-dependent manner. Here we report high-resolution electron cryomicroscopy structures of truncated and full-length TRPV5 in lipid nanodi ...[more]