Dataset Information
Single particle cryo-EM dataset of clathrin cages suitable for subparticle extraction
Ontology highlight
ABSTRACT:
SUBMITTER: Corinne J Smith
PROVIDER: EMPIAR-10295 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly.
Nature structural & molecular biology 20191003 10
Clathrin forms diverse lattice and cage structures that change size and shape rapidly in response to the needs of eukaryotic cells during clathrin-mediated endocytosis and intracellular trafficking. We present the cryo-EM structure and molecular model of assembled porcine clathrin, providing insights into interactions that stabilize key elements of the clathrin lattice, namely, between adjacent heavy chains, at the light chain-heavy chain interface and within the trimerization domain. Furthermor ...[more]