Dataset Information
Cryo-EM structures of human P4-ATPase flippase
Ontology highlight
ABSTRACT:
SUBMITTER: Tomohiro Nishizawa
PROVIDER: EMPIAR-10303 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science (New York, N.Y.) 20190815 6458
In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate the translocation of phospholipids from the outer to the inner leaflet and maintain lipid asymmetry, which is critical for membrane trafficking and signaling pathways. Here, we report the cryo-electron microscopy structures of six distinct intermediates of the human ATP8A1-CDC50a heterocomplex at resolutions of 2.6 to 3.3 angstroms, elucidating the lipid translocation cycle of this P4-ATPase. ATP-dependent pho ...[more]