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Cryo-EM reconstructions of tau filaments in chronic traumatic encephalopathy

ABSTRACT:

SUBMITTER: Sjors Scheres

PROVIDER: EMPIAR-10313 | biostudies-other |

REPOSITORIES: biostudies-other

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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.

Falcon Benjamin B Zivanov Jasenko J Zhang Wenjuan W Murzin Alexey G AG Garringer Holly J HJ Vidal Ruben R Crowther R Anthony RA Newell Kathy L KL Ghetti Bernardino B Goedert Michel M Scheres Sjors H W SHW

Nature 20190320 7752

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is associated with repetitive head impacts or exposure to blast waves. First described as punch-drunk syndrome and dementia pugilistica in retired boxers<sup>1-3</sup>, CTE has since been identified in former participants of other contact sports, ex-military personnel and after physical abuse<sup>4-7</sup>. No disease-modifying therapies currently exist, and diagnosis requires an autopsy. CTE is defined by an abundance ...[more]

PMID: 30894745

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