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Cryo electron microscopy of RyR1 in the presence and abscence of Ca, Caffeine and ATP ligands

ABSTRACT:

SUBMITTER: Abbas Ourmazd

PROVIDER: EMPIAR-10315 | biostudies-other |

REPOSITORIES: biostudies-other

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Retrieving functional pathways of biomolecules from single-particle snapshots.

Dashti Ali A Mashayekhi Ghoncheh G Shekhar Mrinal M Ben Hail Danya D Salah Salah S Schwander Peter P des Georges Amedee A Singharoy Abhishek A Frank Joachim J Ourmazd Abbas A

Nature communications 20200918 1

A primary reason for the intense interest in structural biology is the fact that knowledge of structure can elucidate macromolecular functions in living organisms. Sustained effort has resulted in an impressive arsenal of tools for determining the static structures. But under physiological conditions, macromolecules undergo continuous conformational changes, a subset of which are functionally important. Techniques for capturing the continuous conformational changes underlying function are essent ...[more]

PMID: 32948759

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