Cryo-EM of GLP-1 receptor bound to TT-OAD2 non-peptidic agonist
Ontology highlight
ABSTRACT:
SUBMITTER: Denise Wootten
PROVIDER: EMPIAR-10346 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Activation of the GLP-1 receptor by a non-peptidic agonist.
Zhao Peishen P Liang Yi-Lynn YL Belousoff Matthew J MJ Deganutti Giuseppe G Fletcher Madeleine M MM Willard Francis S FS Bell Michael G MG Christe Michael E ME Sloop Kyle W KW Inoue Asuka A Truong Tin T TT Clydesdale Lachlan L Furness Sebastian G B SGB Christopoulos Arthur A Wang Ming-Wei MW Miller Laurence J LJ Reynolds Christopher A CA Danev Radostin R Sexton Patrick M PM Wootten Denise D
Nature 20200108 7790
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, including diabetes and obesity<sup>1</sup>. Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intracellular side of transmembrane helix 6, resulting i ...[more]
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