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CryoEM dataset of sarkosyl-insoluble fractions from the putamen of multiple system atrophy brain of case 1

ABSTRACT:

SUBMITTER: Yang Shi

PROVIDER: EMPIAR-10357 | biostudies-other |

REPOSITORIES: biostudies-other

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Structures of α-synuclein filaments from multiple system atrophy.

Schweighauser Manuel M Shi Yang Y Tarutani Airi A Kametani Fuyuki F Murzin Alexey G AG Ghetti Bernardino B Matsubara Tomoyasu T Tomita Taisuke T Ando Takashi T Hasegawa Kazuko K Murayama Shigeo S Yoshida Mari M Hasegawa Masato M Scheres Sjors H W SHW Goedert Michel M

Nature 20200527 7825

Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human neurodegenerative diseases<sup>1</sup>. Existing treatments are at best symptomatic. These diseases are characterized by the presence of, and believed to be caused by the formation of, filamentous inclusions of α-synuclein in brain cells<sup>2,3</sup>. However, the structures of α-synuclein filaments from the human brain are unknown ...[more]

PMID: 32461689

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