Whole-body integration of gene expression and single-cell morphology
Ontology highlight
ABSTRACT:
SUBMITTER: Detlev Arendt
PROVIDER: EMPIAR-10365 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Whole-body integration of gene expression and single-cell morphology.
Vergara Hernando M HM Pape Constantin C Meechan Kimberly I KI Zinchenko Valentyna V Genoud Christel C Wanner Adrian A AA Mutemi Kevin Nzumbi KN Titze Benjamin B Templin Rachel M RM Bertucci Paola Y PY Simakov Oleg O Dürichen Wiebke W Machado Pedro P Savage Emily L EL Schermelleh Lothar L Schwab Yannick Y Friedrich Rainer W RW Kreshuk Anna A Tischer Christian C Arendt Detlev D
Cell 20210810 18
Animal bodies are composed of cell types with unique expression programs that implement their distinct locations, shapes, structures, and functions. Based on these properties, cell types assemble into specific tissues and organs. To systematically explore the link between cell-type-specific gene expression and morphology, we registered an expression atlas to a whole-body electron microscopy volume of the nereid Platynereis dumerilii. Automated segmentation of cells and nuclei identifies major ce ...[more]
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