Dataset Information
Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain
Ontology highlight
ABSTRACT:
SUBMITTER: David Kalbermatter
PROVIDER: EMPIAR-10366 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain.
Journal of structural biology: X 20200229
Measles virus (MeV) and canine distemper virus (CDV), two members of the <i>Morbillivirus</i> genus, are still causing important global diseases of humans and animals, respectively. To enter target cells, morbilliviruses rely on an envelope-anchored machinery, which is composed of two interacting glycoproteins: a tetrameric receptor binding (H) protein and a trimeric fusion (F) protein. To execute membrane fusion, the F protein initially adopts a metastable, prefusion state that refolds into a h ...[more]